Dynamics of inflammatory changes of the gastric mucosa in children with duodenal ulcer

Background. The problem of gastrointestinal diseases in children remains quite relevant due to the high prevalence and presence atypical symptoms comorbidities pathogenetically associated with acid-dependent diseases. purpose was study dynamics inflammatory changes mucous membrane duodenal ulcer (DU). Materials methods. One hundred six aged 10 18 years DU were examined. To verify diagnosis, all underwent endoscopy, pH-metry, morphological examination gastrobiopsy samples, for Helicobacter pylori (H.pylori). Results. 49.1 % diagnosed impaired motor-evacuatory function form duodenogastric and/or gastrooesophageal reflexes, 81.1 patients presented H.pylori determined. Erythematous gastric mucosa predominated. 92.4 chronic non-atrophic gastritis gastroduodenitis varying degrees inflammation, 7.6 — atrophic gastritis. There a decrease height signs desquamation superficial epithelium, 72.3 development granular dystrophy, 6.9 without infection 57.5 infected neutrophilic infiltration membrane. In after 3 months, epithelium frequency desquamative decreased, proliferation glandular 12.4 increased. Conclusions. Morphological biopsies differ depending on partially persist months treatment.